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IRCT2012120311656N1 IRCT 2012-12-23 ُShiraz University of Medical Sciences Comparing the effects of cryotherapy and local corticosteroids in the treatment of oral lichen planus lesions Comparing the effects of cryotherapy and local corticosteroids in the treatment of oral lichen planus lesions 2012-12-20 anticipated 30 Complete https://irct.ir/trial/11828 interventional Randomization: Randomized, Blinding: Single blinded, Placebo: Not used, Assignment: Parallel, Purpose: Treatment. N/A Oral lichen planus. Intervention 1: Control Group: Topical corticosteroid in orabase. Intervention 2: Intervention: Cryotherapy with N2O gass. http://www.ijdr.in/article.asp?issn=0970-9290;year=2014;volume=25;issue=6;spage=711;epage=716;aulast=Amanat Background: Oral lichen planus (OLP) is a chronic inflammatory disease of the oral mucosa with treatment challenges for clinicians.<br /> Aims: The objective of this study is to compare the effects of cryotherapy as a new modality with topical corticosteroids as a conventional therapy in the treatment of OLP.<br /> Materials and Methods: Thirty patients with bilateral OLP lesions were selected. From each patient a lesion on one side was chosen randomly for a single session of cryotherapy with nitrous oxide gas and the lesion on the other side received triamcinolone acetonide 0.1% ointment orabase. Treatment outcome was measured by means of an appearance score, pain score (visual analogue scale), and severity of lesions before treatment and after 2, 4 and 6 weeks of treatment.<br /> Statistical Analysis Used: Paired samples t‑test and Wilcoxon test.<br /> Results: In both methods of treatment sign score, pain score and severity of lesions was significantly reduced in all follow‑up sessions (P < 0.05). But the treatment outcome and relapse was not significantly different between the two treatment methods (P > 0.05)<br /> Conclusion: Cryotherapy with nitrous oxide gas is as effective as topical triamcinolone acetonide in the treatment of OLP with no systemic side effects and needs less patient compliance. It can be considered as an alternative or adjuvant therapy in OLP patients to reduce the use of treatments with adverse effects.
public Dr. Maryam Zahed
ghasrodasht, Ghomabad, Shiraz Dental School
Shiraz Iran (Islamic Republic of) +98 71 1648 6702 maryamzhd@yahoo.com Shiraz University of Medical Sciences, Dental school scientific Dr. Dariush Amanat
Ghasrodasht, Ghomabad, Shiraz Dental School
Shiraz Iran (Islamic Republic of) +98 71 1628 6777 amanatd@sums.ac.ir Shiraz University of Medical Sciences, Dental school Iran (Islamic Republic of) Inclusion criteria: • Clinical diagnosis of oral lichen planus • Existence of two lesions with similar clinical appearance (with the size difference of less than 1 cm) on the right and left buccal mucosa or right and left side of tongue • Not received any treatment for the lesions for at least 2 weeks ago • Signing the consent form. Exclusion criteria: • Using drugs that are proved to develop lichenoid lesions. • Lesions seen in contact with dental amalgam • Coexisting dermal and genital lesions • Hypersensitivity to drugs being used • Pregnant women • Systemic disease such as systemic lupus erythematosus, erythema multiform, secondary syphilis, graft versus host disease or others systemic disease. no limit no limit Both L43 Treatment - Drugs Treatment - Devices Control Group: Topical corticosteroid in orabase Intervention: Cryotherapy with N2O gass Reduction in severity of lesions. Timepoint: 2 weeks after treatment. Method of measurement: cilinical judgement of a capable cilinician. Lesion size. Timepoint: 2, 4, 6, 8, 10, 12 weeks after treatment. Method of measurement: with a digital culis. Pain. Timepoint: 2, 4, 6, 8, 10, 12 weeks after treatment. Method of measurement: Visual analogue score. Patient satisfaction of each individual treatment. Timepoint: 3 months after treatment. Method of measurement: by asking the patient to give a percentage of satisfaction for each side. ُShiraz University of Medical Sciences Approved 2012-10-04 Shiraz University of Medical Sciences Zand street Shiraz Iran (Islamic Republic of)