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IRCT2013091714690N1 IRCT 2014-02-26 Vice-chancellor for Research the Technology, Hamadan University of Medical Sciences The effect of omega-3 versus placebo on acne in patients aged 13-50 years The effect of omega-3 versus placebo on acne in patients aged 13-50 years: a triple blinded randomized clinical trial 2012-09-22 anticipated 60 Complete https://irct.ir/trial/14247 interventional Randomization: Randomized, Blinding: Triple blinded, Placebo: Used, Assignment: Parallel, Purpose: Treatment, Other design features: Randomization: 30 envelopes containing the letters A (intervention group) and 30 envelopes containing the letters B (control group) will be numbered from one to 60 based on a table of random numbers. Then, the patients will be assigned to each envelope in order. Blinding: The patients will receive either Omega-3 capsule or placebo (starch) capsule with the same shape but different content. Thus, they will not aware of the intervention. In addition, the examiner, who will assess the results of intervention, and the analyzer of the data will not aware of the type of treatment received by the patients. Thus, the trial will be run as triple blinded. 2 Acne. Intervention 1: Oral doxycycline 100 mg daily plus oral 1000 mg omega-3, daily, for 12 weeks. Intervention 2: Oral doxycycline 100 mg daily plus oral placebo including starch, daily, for 12 weeks.
public Dr Hassan Faghani
School of Medicine, Hamadan University of Medical Sciences, Shahid Fahmideh Ave.
Hamadan Iran (Islamic Republic of) 6517838695 +98 81 1838 0717 dr.faghani@yahoo.com Department of Dermatology scientific Dr Hassan Faghani
School of Medicine, Hamadan University of Medical Sciences, Shahid Fahmideh Ave.
Hamadan Iran (Islamic Republic of) 6517838695 +98 81 1838 0717 dr.faghani@yahoo.com Department of Dermatology Iran (Islamic Republic of) Inclusion criteria: having moderate to severe facial acne vulgaris. Exclusion criteria: (a) being immunodeficient; (b) contraindication of acne treatment; (c) using medications which have interaction with omega-3. 13 years 50 years Both L70 Acne Treatment - Drugs Placebo Oral doxycycline 100 mg daily plus oral 1000 mg omega-3, daily, for 12 weeks. Oral doxycycline 100 mg daily plus oral placebo including starch, daily, for 12 weeks The severity of acne. Timepoint: at the end of sixth and twelfth weeks. Method of measurement: based on global acne grading system. Vice-chancellor for Research the Technology, Hamadan University of Medical Sciences Approved 2012-08-18 Research Ethic Committee of Hamadan University of Medical Sciences Vice-chancellor of Research the Technology, Hamadan University of Medical Sciences, Shahid Fahmideh Ave Hamadan Iran (Islamic Republic of)