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IRCT2015021019470N16 IRCT 2015-04-21 Vice Chancellor for Research, Shiraz University of Medical Sciences Comparison of Changes in Heart Rate following Reversal of Muscle Relaxation by Two Combination :Atropine Plus Neosigmine or Glycopyrrolate Plus Neostigmin Comparison of Changes in Heart Rate and Development Cardiac Arrhythmia following Reversal of Muscle Relaxation by Two Combination :Atropine Plus Neosigmine or Glycopyrrolate Plus Neostigmin 2010-08-23 anticipated 100 Complete https://irct.ir/trial/17398 interventional Randomization: Randomized, Blinding: Double blinded, Placebo: Not used, Assignment: Parallel, Purpose: Treatment. 2 Cataract. Intervention 1: at the end of the operation reversal of the muscle relaxant effects in group I was conducted with combination of atropine-neostigmine. Intervention 2: at the end of the operation reversal of the muscle relaxant effects in group ІІ was conducted with combination of glycopyrrolate-neostigmine .
public Dr Mehdi Zadmehr
Department of anesthesia, Faghihi Hospital, Zand Street
Shiraz Iran (Islamic Republic of) +98 71 3647 4270 masihifarzaneh@yahoo.com Shiraz University of Medical Sciences scientific Mansoor Masjedi
Anesthesiology Office, Namazi Hospital
Shiraz Iran (Islamic Republic of) +98 71 3647 4270 mansoormasjedi@yahoo.com Shiraz University of Medical Sciences Iran (Islamic Republic of) Inclusion criteria: patient between 50-70 year old, ASA physical status I, undergoing cataract surgery under general anesthesia with endotracheal tube or laryngeal mask. Exclusion criteria: Patients with electrolyte abnormalities, cardiovascular problems and using the drugs that affect heart rate and also patients with difficult intubation were excluded from the study. 50 years 70 years Both H25 Senile Cataract Treatment - Drugs Treatment - Drugs at the end of the operation reversal of the muscle relaxant effects in group I was conducted with combination of atropine-neostigmine at the end of the operation reversal of the muscle relaxant effects in group ІІ was conducted with combination of glycopyrrolate-neostigmine . Heart Rate. Timepoint: 1) before induction of anesthesia .2) after administration of anesthetic drugs and before drug reversal of muscle relaxation 3) Three minutes after reversal of neuromuscular blockade. 4) ten minutes after reversal of neuromuscular blockade. Method of measurement: EKG. Arrhythmia. Timepoint: 1) before induction of anesthesia .2) after administration of anesthetic drugs and before drug reversal of muscle relaxation 3) Three minutes after reversal of neuromuscular blockade. 4) ten minutes after reversal of neuromuscular blockade. Method of measurement: EKG. Blood Pressure. Timepoint: 1) before induction of anesthesia .2) after administration of anesthetic drugs and before drug reversal of muscle relaxation 3) Three minutes after reversal of neuromuscular blockade. 4) ten minutes after reversal of neuromuscular blockade. Method of measurement: Measuring the blood pressure. Vice Chancellor for Research, Shiraz University of Medical Sciences Approved 2010-08-20 Ethic Committee of Shiraz University Of Medical Sciences Central Building of Shiraz University of Medical Sciences, Zand Street Shiraz Iran (Islamic Republic of)