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IRCT201212043386N8 IRCT 2012-12-10 Semnan University of Medical Sciences Effects of simvastatin on clomiphen response in clomiphen – resistant women with polycystic ovary syndrome Effects of simvastatin on clomiphen response in clomiphen – resistant women with polycystic ovary syndrome 2009-05-01 anticipated 25 Complete https://irct.ir/trial/3468 interventional Randomization: N/A, Blinding: Not blinded, Placebo: Not used, Assignment: Single, Purpose: Treatment. N/A Polycystic ovary syndrome. We enrolled 25 anovulatory PCOS women who failed to ovulate by using only CC . All patients received cyclic oral contraceptives (30µg of ethinyl estradiol and 150µg of desogestrol) from the 5th day of their spontaneous or progesterone(P) induced menstrual cycle plus simvastatine (20mg/day)) from the first day of cycle for 2 months. Then patients were given100 mg CC (Clomid, Iran Hormone) for 5 days starting from day 3 of their menstrual cycle.
public Azam Azargoon
Madar square, Amiralmomenin Hospital
Semnan Iran (Islamic Republic of) +98 23 1446 0077 a-azargoon@sem-ums.ac.ir Semnan University of Medical Sciences scientific Azam Azargoon
Madar square, Amiralmomenin hospital
Semnan Iran (Islamic Republic of) 3519734731 +98 23 1446 0077 a-azargoon@sem-ums.ac.ir Semnan University of Medical Sciences Iran (Islamic Republic of) The inclusion criteria: women who were 18-40 years of age, with a period of infertility more than 1.5 years and normal serum prolactin and thyroid function tests, they all had documented patent tubes by hysterosalpingography, had no other infertility factor, and failed to ovulate with a dose of CC of 150 mg /day for 5 days from day 3 of the period. The women who were diabetic, had hypertension or abnormal renal or liver function tests, and had undergone ovarian drilling were excluded from the study. Hirsutism was diagnosed when the Ferriman and Gallway score was >8(15). The diagnosis of PCOS was according to the Rotterdam Criteria 18 years 40 years Female E28.2 Polycystic ovarian syndrome Treatment - Drugs We enrolled 25 anovulatory PCOS women who failed to ovulate by using only CC . All patients received cyclic oral contraceptives (30µg of ethinyl estradiol and 150µg of desogestrol) from the 5th day of their spontaneous or progesterone(P) induced menstrual cycle plus simvastatine (20mg/day)) from the first day of cycle for 2 months. Then patients were given100 mg CC (Clomid, Iran Hormone) for 5 days starting from day 3 of their menstrual cycle Ovulation and pregnancy rates. Timepoint: after intervention. Method of measurement: BHCG and sonography. Change in BMI,. Timepoint: After intervention. Method of measurement: BMI=WT(kg)/H2(m). Endometrial thickness. Timepoint: On HCG day adminstration. Method of measurement: Sonography. Size and numbers of follicles>18mm. Timepoint: On HCG day adminstration. Method of measurement: Sonography. Semnan University of Medical Sciences Approved 2009-04-21 Semnan Uiversity of Medical Sciences Basij blvd Semnan Iran (Islamic Republic of)