IRCT20180519039711N4 IRCT 2020-02-04 Arak University of Medical Sciences Effect of silymarin on the liver and pain of rheumatoid arthritis patients Effect of Silybum marianum on methotrexate-induced hepatotoxicity and its analgesic effect in the patients with rheumatoid arthritis history 2020-02-20 anticipated 60 Complete https://irct.ir/trial/45141 interventional Randomization: Randomized, Blinding: Double blinded, Placebo: Used, Assignment: Parallel, Purpose: Treatment, Randomization description: Patients will be randomly divided into intervention and control groups. Sixty patients were randomly assigned to either the intervention or control groups, initially 6 blocks of 10 different T and C letters (which represent the intervention and control groups) (30) from the intervention group and 30 from the intervention group. People belong to the control group). Then, the blocks were randomly selected to obtain a 60-sided combination of blocks. It opens to tell which group the patient falls into, Blinding description: Clinical caregivers, data analysts, and patients are not aware of being in the control or intervention group. 3 Rheumatoid arthritis. Intervention 1: Intervention group: Take daily with oral 280-mg Silymarin ‎For 2 months. Intervention 2: Control group: Control group take under the administration of placebo. Yes - There is a plan to make this available What will be shared: The information will be published in the final report and article. When: The information will be published in the final report and article. To whom: The information will be published in the final report and article. Conditions: The information will be published in the final report and article. Where to obtain: The information will be published in the final report and article. How to obtain: The information will be published in the final report and article. Comments: