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IRCT20110531006660N9 IRCT 2020-07-24 Mazandaran University of Medical Sciences Probitic in chronic urticaria Effect probiotic on resistant chronic urticaria 2020-07-22 anticipated 40 Complete https://irct.ir/trial/49671 interventional Randomization: Randomized, Blinding: Double blinded, Placebo: Used, Assignment: Parallel, Purpose: Treatment, Randomization description: Simple randomization, each patient selected based on table of random divided to each group . such as 1,4,7 and ...in one group; 2,3,5,6,8,9 and ...in another group based on randomization number, Blinding description: All of participants, physician, data collector, data analyzer. after selection of patients, take drug or placebo from pharmacy. only pharmacologist known about treatment. finally data send to supervisor without name and without kind of treatment. 3 Chronic urticaria. Intervention 1: Intervention group: 20 patient with CU resistant to treatment treated with cetirizine 10mg BID/day and probiotic 1000 mg /day for 8 weeks. all of them completing questionnaire before, 4 and 8 weeks after treatment. Intervention 2: Control group: 20 patient with CU resistant to treatment treated with cetirizine 10mg BID/day and placebo one cap sol /day for 8 weeks. all of them completing questionnaire of severity and quality of life before, 4 and 8 weeks after treatment. Yes - There is a plan to make this available What will be shared: Yes When: After end of research To whom: All Conditions: No Where to obtain: Email How to obtain: Email Comments:
public Javad Ghaffari
Pasdaran blvd
Sari Iran (Islamic Republic of) 4815838477 +98 11 3326 0054 Javadneg@Yahoo.com Mazandaran University of Medical Sciences scientific Javad Ghaffari
Pasdaran blvd
Sari Iran (Islamic Republic of) 4815838477 +98 11 3326 0054 Javadneg@Yahoo.com Mazandaran University of Medical Sciences Iran (Islamic Republic of) Resistant chronic urticaria 5 to 30 years old 5 years 30 years Both Consumption of probiotic in the last 2 months Second urticaria other Known disorders consumption of antibiotic in the last 2 months L50.1 Idiopathic urticaria Treatment - Drugs Treatment - Drugs Intervention group: 20 patient with CU resistant to treatment treated with cetirizine 10mg BID/day and probiotic 1000 mg /day for 8 weeks. all of them completing questionnaire before, 4 and 8 weeks after treatment. Control group: 20 patient with CU resistant to treatment treated with cetirizine 10mg BID/day and placebo one cap sol /day for 8 weeks. all of them completing questionnaire of severity and quality of life before, 4 and 8 weeks after treatment. Resolution chronic urticaria severity. Timepoint: Before, 4 and 8 weeks after treatment. Method of measurement: Questionnaire- UAS7 and QOLI. Resolution chronic urticaria quality of life. Timepoint: Before, 4 and 8 weeks after treatment. Method of measurement: Questionnaire. Mazandaran University of Medical Sciences Approved 2018-08-20 Ethics committee of Mazandaran University of Medical sciences Pasadaran Blvd-Boali hospital Sari Mazandaran Iran (Islamic Republic of)