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IRCT201010124917N1 IRCT 2011-01-20 Vice-chancellor for Research, Ahvaz Jundishapur University of Medical Sciences Therapeutic effect of herbal formulation Hypericum perforatum with antidepressant drug A comparison of tricyclic antidepressant augmentation with herbal formation Hypericum perforatum and placebo in depressed outpatients referred to psychiatric clinic and Golestan hospital / Ahvaz /Iran 2010-07-23 anticipated 40 Complete https://irct.ir/trial/5257 interventional Randomization: Randomized, Blinding: Double blinded, Placebo: Used, Assignment: Parallel, Purpose: Treatment. 2-3 Condition 1: Moderate depression. Condition 2: Mild depression. Intervention 1: Tricyclic antidepressant with average dose, as well as Hypericum Perforatum (a herbal formulation), three times a day 6 weeks. Intervention 2: Tricyclic antidepressant with average dose, as well as placebo, three times a day 6 weeks.
public Dr. Zhale Nilsaz
Unit 3, Number 9, East Elham St., Kianpars
Ahvaz Iran (Islamic Republic of) +98 61 1333 8770 drbabapour@yahoo.com Ahvaz Jundishapur University of Medical Sciences scientific Dr. Sirus Pakseresht
Unit 5, Number 110, sixth St., Kianpars west
Ahvaz Iran (Islamic Republic of) +98 61 1338 3124 Pakseresht@ajums.ac.ir Ahvaz Jundishapur University of Medical Sciences Iran (Islamic Republic of) Iran (Islamic Republic of) Inclusion criteria: Major depressive disorder diagnosed by a psychiatrist based on DSM-IV-TR criteria, age range between 18-55 years, filling the consent form, mild or moderate severity of depression Exclusion Criteria: Pregnancy, breast feeding, organic or neurological disorder featuring both clinically, Axis II psychiatric disorder, presence of simultaneous psychiatric disorder diagnosis in axis I, using alcohol and other addictive substances other than nicotine and caffeine in a one-month past, exacerbation of symptoms of severe depression or psychotic disorders, Signs that require hospitalization and emergency action such as suicidal thoughts and behaviors, Not receiving ECT over three months prior to the study, any particular sensitivity to plant grass herbal tea, consumption of medicine such as lithium, anticonvulsants, sumatriptan, Al Biped, serotonin-reuptake inhibitors, buspirone, Argo compounds, Selegiline, stimulants, anti-congestive, contraceptives, cimetidine, theophylline or thyroid hormones during 7 days prior to the study 18 years 55 years Both F32.1 F 32.0 Moderate depressive episode Mild depressive episode Treatment - Drugs Placebo Tricyclic antidepressant with average dose, as well as Hypericum Perforatum (a herbal formulation), three times a day 6 weeks Tricyclic antidepressant with average dose, as well as placebo, three times a day 6 weeks Improvement of sleep. Timepoint: 3 weeks. Method of measurement: clinical interview. Improvement of apetite. Timepoint: 3 weeks. Method of measurement: clinical interview. Treatment of depression. Timepoint: 3 weeks. Method of measurement: Beck Rating Scale for Depression. Vice-chancellor for Research, Ahvaz Jundishapur University of Medical Sciences Approved 2010-04-18 Ahvaz Jundishapur Univercity of Medical Sciences Golestan boulevard Ahvaz Iran (Islamic Republic of)