IRCT20180401039166N1 IRCT 2025-01-31 Shahid Beheshti University of Medical Sciences Comparison of Intramuscular vs Intravenous Sedation in Dental Treatment Comparison of the Sedative Effects of Intramuscular vs Intravenous of Ketamine, Midazolam and Atropine Cocktail in 2‒6-Year-Old Uncooperative Dental Patients 2025-01-04 anticipated 32 Complete https://irct.ir/trial/78292 interventional Randomization: Randomized, Blinding: Double blinded, Placebo: Not used, Assignment: Crossover, Purpose: Treatment, Randomization description: The samples will be divided into two groups of intramuscular and intravenous sedation by simple randomization method. The randomization unit will be independent individuals and the samples will be assigned into two groups using the individual randomization table, Blinding description: 1. Participants: Parents will know about participating in the study and performing treatment with intramuscular or intravenous sedation in two sessions, but they will be blinded to the type of sedation in each session. 2. Researcher and clinical caregiver: is responsible for performing dental treatment and is blinded to the sedation method (intramuscular or intravenous) used by the anesthesiologist. 3. Data Analyst: Data will be analyzed by a statistician who is unaware of the sedation method. 3 Intramuscular and intravenous sedation. Intervention 1: Intervention group: Intramuscular injection:Drugs used in the intramuscular group include the combination of 6 mg/kg of ketamine (500 mg/10 ml, EXIR, Iran), 0.05 mg/kg of midazolam (0.5 mg/ml, EXIR, Iran) and 0.02 mg/kg of atropine ( 0.5 mg/ml, Daroupakhsh, Iran). Intervention 2: Intervention group: Intravenous injection: In the intravenous group, it will include 2 mg/kg of ketamine(500 mg/10 ml, EXIR, Iran), 0.0.2 mg/kg of midazolam(0.5 mg/ml, EXIR, Iran) and 0.02 mg/kg of atropine( 0.5 mg/ml, Daroupakhsh, Iran). No - There is not a plan to make this available Justification or reason for not sharing IPD is In order to protect the privacy and medical information of patients