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IRCT20190128042525N7 IRCT 2024-11-01 Rafsanjan University of Medical Sciences Effect of Topical Pistacia Atlantica Oil on some Clinical symptoms of Knee Osteoarthritis Effect of Topical Pistacia Atlantica Oil on some Clinical of Knee Osteoarthritis: a Randomized and Double Blind Clinical Trial 2024-10-22 anticipated 50 Complete https://irct.ir/trial/79125 interventional Randomization: Randomized, Blinding: Double blinded, Placebo: Used, Assignment: Parallel, Purpose: Treatment, Randomization description: In this study, in order to reduce bias and increase the reliability of the results, patients were assigned to three groups using a table of random numbers. In this way, the researcher first considered the direction of reading the numbers as a left-to-right convention. Then he assigned numbers 00-30 to group A, numbers 31-60 to group B, and numbers 61-90 to group C. Then the researcher put his hand on one of the numbers and recorded the numbers from left to right and assigned them to different groups. To hide the random allocation (allocation concealment), drugs and placebo were placed in the same packages and coded as A, B, and C. In the randomization process, the person involved in creating the randomization plan was separate from other researchers, to reduce possible bias, Blinding description: Before starting the study, the drugs will be placed in the same packages by someone other than the researcher and coded as A, B, and C. Medicines are prescribed by a rheumatology specialist in the form of medicine A or B or C and the medicine is delivered by another person. The evaluation of clinical symptoms is done by the internal resident, who does not know the type of medicine used by each person, and based on the relevant protocol (which is explained below). 3 Osteoarthritis. Intervention 1: Intervention group A: Group A will use piroxicam gel topically. The duration of treatment is 3 months and twice a day. In addition, patients will be allowed to use oral analgesics drugs as needed to relieve their pain. Intervention 2: Intervention group B: Group B will use topical Pistacia Atlantica oil to relieve pain. The duration of treatment is 3 months and twice a day. During the study, patients are only allowed to use oral painkillers once a day if needed, and none of the common drugs will be used during this period. Intervention 3: Control group: In group C, paraffin will be used for placebo and to compare their effects.The duration of treatment is 3 months and twice a day. During the study, patients are only allowed to use oral painkillers once a day if needed, and none of the common drugs will be used during this period. No - There is not a plan to make this available Justification or reason for not sharing IPD is There is no further information
public Gholamreza Bazmandegan
Ali Ibn_Taleb Blvd
Rafsanjan Iran (Islamic Republic of) 7717937555 +98 34 3428 0185 clinical.research@rums.ac.ir Rafsanjan University of Medical Sciences scientific Zahra Kamiab
Fars Gulf Blvd - Pistachio Blvd - University of Medical Sciences Campus - Faculty of Medicine
Rafsanjan Iran (Islamic Republic of) 37718175911 +98 34 3428 0185 dr.kamiab89@gmail.com Rafsanjan University of Medical Sciences Iran (Islamic Republic of) Age 50-70 The diagnosis of knee osteoarthritis is based on the criteria of the American College of Rheumatology, which is confirmed by a rheumatology specialist. The presence of average knee pain during 24 hours based on the linear-visual pain scale (VAS) between 4 and 7 cm. 50 years 70 years Both Patients suffering from inflammatory diseases (such as lupus, rheumatoid arthritis, history of brucellosis, etc.) Cancer or serious diseases, symptoms or history of liver or kidney failure, Taking oral corticosteroids during the last 4 weeks corticosteroids injection in the last 6 months. fever Consuming medicinal plants continuously Allergy to the Pistacia Atlantica unwillingness to continue participating in the stud Failure to comply with the study protocol Observing any side effects that the patient thinks are caused Pistacia Atlantica by oil. M17 Osteoarthritis of knee Treatment - Drugs Treatment - Drugs Placebo Intervention group A: Group A will use piroxicam gel topically. The duration of treatment is 3 months and twice a day. In addition, patients will be allowed to use oral analgesics drugs as needed to relieve their pain. Intervention group B: Group B will use topical Pistacia Atlantica oil to relieve pain. The duration of treatment is 3 months and twice a day. During the study, patients are only allowed to use oral painkillers once a day if needed, and none of the common drugs will be used during this period. Control group: In group C, paraffin will be used for placebo and to compare their effects.The duration of treatment is 3 months and twice a day. During the study, patients are only allowed to use oral painkillers once a day if needed, and none of the common drugs will be used during this period. Knee pain intensity. Timepoint: At the beginning and the end of the study (three months after the beginning of the study). Method of measurement: Visual Analogue Scale (VAS). Rafsanjan University of Medical Sciences Approved 2019-11-11 Ethics committee of Rafsanjan University of Medical Sciences Ali Ibn Abitaleb Blvd Rafsanjan Kerman Iran (Islamic Republic of)