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IRCT20250308064981N1 IRCT 2026-07-09 Kashan University of Medical Sciences DBT for people with Multiple Sclerosis The Effectiveness of Dialectical Behavior Therapy (DBT) on mood swings, Intolerance of Uncertainty and interpersonal problems in women with Multiple Sclerosis (MS) 2025-05-19 anticipated 40 Complete https://irct.ir/trial/82296 interventional Randomization: Randomized, Blinding: Not blinded, Placebo: Not used, Assignment: Other, Purpose: Supportive, Randomization description: Initially, patients interested in participating in the study were examined by a neurologist (with an MS fellowship) and underwent an initial interview with a psychologist (the researcher). Patients meeting the study's inclusion criteria were identified and selected using purposive sampling. During the first meeting, to adhere to ethical guidelines, the researcher provided participants with information regarding the study (number and duration of sessions, session format, etc.), randomization (assignment to experimental or control groups), data confidentiality, and the right to withdraw from the study at any time; informed consent for participation was then obtained. Following the matching of participants based on age and education, assignment to the experimental and control groups was carried out randomly using a table of random numbers. A random number table consists of a large set of numbers generated entirely at random without any discernible pattern or order and arranged in a tabular format. To utilize the table, a method was employed in which even numbers were assigned to the experimental group and odd numbers to the control group. Furthermore, the two groups were matched regarding all known factors and confounding variables. N/A Multiple Sclerosis. Intervention 1: Intervention group: First, the participants will be given a pre-test. The pre-test includes 3 questionnaires to assess and measure dependent variables. Then, the intervention group will receive dialectical behavior therapy for 3 months (12 sessions, one session per week) and finally, they will be given a post-test. Intervention 2: Control group: Participants will first be given a pre-test. They will not receive any psychological treatment and will only receive their usual medication. Then they will be given a post-test. Yes - There is a plan to make this available What will be shared: Demographic information including: age, education, marital status, employment status; duration of illness. Information related to participants' scores on questionnaires measuring the variables under study. Data entered into SPSS program When: 6 months after results are published To whom: Researchers working in universities and scientific centers Conditions: For research and articles in the fields of psychology, psychiatry, neurology and neuroscience Where to obtain: fatemehshams.psy@gmail.com How to obtain: Go to the email listed on the site and submit a request Comments:
public Fateme Shamsi
3th floor, No. 8, gole sorkh alley, hashemi street, golha town, Eslamshahr, Tehran, Iran
Tehran Iran (Islamic Republic of) 3315683748 +98 21 5612 0880 fatemehshams.psy@gmail.com Kashan University of Medical Sciences scientific Zahra Zanjani
Kargarnejad Educational and Therapeutic Medical, 5 km from Qotb Rawandi - end of Parstar Boulevard, kashan Center,
Kashan Iran (Islamic Republic of) 8715973474 +98 31 5558 9212 z_zanjani2005@yahoo.com Kashan University of Medical Sciences Iran (Islamic Republic of) Received a diagnosis of Multiple Sclerosis (MS) from a neurologist Gender : Female Age 20-45 years Expanded Disability Status Scale (EDSS) score less than 4 Settling in inactive periods of the disease (stable, no relapse, no new lesions on MRI) 20 years 45 years Female Suffering from chronic psychological disorders such as depression, anxiety, psychotic disorders, and bipolar disorder. Suffering from chronic physical conditions such as high blood pressure, diabetes, lung diseases, and heart diseases. Receiving concurrent psychological treatment Receiving corticosteroid pulse therapy (methylprednisolone) within the last month Suicidal thoughts G35 Multiple sclerosis Rehabilitation Other Intervention group: First, the participants will be given a pre-test. The pre-test includes 3 questionnaires to assess and measure dependent variables. Then, the intervention group will receive dialectical behavior therapy for 3 months (12 sessions, one session per week) and finally, they will be given a post-test. Control group: Participants will first be given a pre-test. They will not receive any psychological treatment and will only receive their usual medication. Then they will be given a post-test. Mood swings score in the PANAS positive and negative mood questionnaire. Timepoint: A pre-test will be taken before the intervention begins, and a post-test will be taken after the intervention (3 months). Method of measurement: Positive and Negative Emotion Scale (PANAS). Tolerance of Uncertainty score on the Freestone Intolerance of Uncertainty Questionnaire (IUS_27). Timepoint: A pre-test will be taken before the intervention begins, and a post-test will be taken after the intervention (3 months). Method of measurement: Freestone Intolerance of Uncertainty Scale (IUS_27). Interpersonal Problems Score on the Barkham Inventory of Interpersonal Problems(IIP-32). Timepoint: A pre-test will be taken before the intervention begins, and a post-test will be taken after the intervention (3 months). Method of measurement: Barkham Inventory of Interpersonal Problems(IIP-32). Tehran University of Medical Sciences Kashan University of Medical Sciences Tehran University of Medical Sciences Approved 2025-03-08 Ethics committee of Kashan University of Medical Sciences Room 3529, Research Vice-Chancellor, Kashan University of Medical Sciences, 5th km of Ravand Road, kashan kashan Isfehan Iran (Islamic Republic of)