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IRCT20250412065291N2 IRCT 2025-09-29 Ilam University of Medical Sciences Studying the effect of curcumin on acne Comparison of the effectiveness of doxycycline capsules with and without curcumin capsules in the treatment of patients with acne vulgaris 2024-05-25 anticipated 200 Complete https://irct.ir/trial/82977 interventional Randomization: Randomized, Blinding: Not blinded, Placebo: Not used, Assignment: Parallel, Purpose: Treatment, Randomization description: Random allocation through drawing a piece of paper from a bag: First, 100 letters A and 100 letters B are written on special papers that contents are not visible. Then all of them are placed in a bag and for each patient, after obtaining informed consent, a paper is taken out randomly and without replacement, and based on the letter written on it, the desired intervention is performed for the patient. In addition, interventions A or B are determined by drawing a card. 3 Acne vulgaris. Intervention 1: Intervention group: Patients in Group A will receive 100 mg of doxycycline. The medication will be prescribed for 12 weeks, with participants taking one capsule daily in the morning on an empty stomach. Intervention 2: Control group: Patients in group B will receive a capsule containing 100 mg of doxycycline and 500 mg of curcumin. The medication will be prescribed for 12 weeks, with participants taking one capsule daily in the morning on an empty stomach. Undecided - It is not yet known if there will be a plan to make this available Justification or reason for indecision in sharing IPD is No further information available
public Shokofeh Sharifi
Ilam University of Medical Sciences, Banganjab
Ilam Iran (Islamic Republic of) 6931851147 +98 84 3222 3721 sharifi-s@medilam.ac.ir Ilam University of Medical Sciences scientific Shokofeh Sharifi
Ilam University of Medical Sciences, Banganjab
Ilam Iran (Islamic Republic of) 6931851147 +98 84 3222 3721 sharifi-s@medilam.ac.ir Ilam University of Medical Sciences Iran (Islamic Republic of) Having moderate to severe acne vulgaris consenting to participate in the study no limit no limit Both Prescription of topical or systemic medications that could potentially interfere with our treatment course Anti-acne treatment in the past two weeks Symptoms of hyperandrogenism Irregular menstrual cycles Acne fulminans Acne conglobata Liver dysfunction L70.0 Acne vulgaris Treatment - Drugs Treatment - Drugs Intervention group: Patients in Group A will receive 100 mg of doxycycline. The medication will be prescribed for 12 weeks, with participants taking one capsule daily in the morning on an empty stomach. Control group: Patients in group B will receive a capsule containing 100 mg of doxycycline and 500 mg of curcumin. The medication will be prescribed for 12 weeks, with participants taking one capsule daily in the morning on an empty stomach. Area of ​​acne scars. Timepoint: Measurement of inflammatory lesions 3 months after intervention. Method of measurement: Measuring with a ruler. Ilam University of Medical Sciences Approved 2024-03-11 Ethics committee of Ilam University of Medical Sciences Banganjab-Ilam university of medical science Ilam Ilam Iran (Islamic Republic of)