IRCT20210228050535N4 IRCT 2025-04-28 Mazandaran University of Medical Sciences The treatment of bone non-union by exosome therapy The effectiveness of injection of mesenchymal stem cells' exosome in the treatment of bone non-union 2025-05-05 anticipated 10 Complete https://irct.ir/trial/82995 interventional Randomization: N/A, Blinding: Not blinded, Placebo: Not used, Assignment: Single, Purpose: Treatment. 1 Nonunion of fracture. Intervention group: In the operating room after prep and drape, under sterile conditions under C-arm, first aspiration of the area secretion for culture is performed and then exosome injection is performed. After exosome injection, one cc of hyaluronic acid will be injected to maintain this substance in place. Finally, the patient is treated with antibiotic prophylaxis (cephalexin 500 capsules every 6 hours) for three days. The injection site is examined for inflammatory reaction on the third day and a week after the injection. The patient will be followed up for six months and during this period, radiographs will be performed four times at 45-day intervals to determine the progress of the union. Finally, after the injection, patients will be followed up for six months and during this period, radiographs will be performed four times (at 45-day intervals) to determine the progress of the union.. Undecided - It is not yet known if there will be a plan to make this available Justification or reason for indecision in sharing IPD is no data available