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IRCT20250428065513N1 IRCT 2025-11-05 Zahedan University of Medical Sciences Studying the effect of PRF on outcomes of impacted third molar surgery PRF(Platelet Rich Fibrin) Studying the effect of Platelet-Rich Fibrin (PRF) on pain, swelling, and ecchymosis after impacted third molar surgery 2025-11-22 anticipated 34 Complete https://irct.ir/trial/83195 interventional Randomization: Randomized, Blinding: Not blinded, Placebo: Not used, Assignment: Parallel, Purpose: Treatment, Other design features: An open-label randomized clinical trial study with parallel groups and phases 3 on 34 patients. Randomization will be done with the block randomization method using Random allocation software, Randomization description: Patients will be divided into intervention and control groups using block randomization based on generated numbers by Random allocation software. Thus, in this software, first the number of groups and the total number of the sample size will be entered (34 patients), and then in the block section, the Block randomization method will be selected. Patients will be allocated in intervention or control groups based on generated numbers. 3 Impacted third molar surgery. Intervention 1: Intervention group: For patients in the intervention group, following anesthesia administration via injection of the local anesthetic 2% Lidocaine, a full-thickness mucoperiosteal flap will be raised with a distal releasing incision relative to the third molar to achieve access. Following the removal of the impacted tooth and irrigation of the socket with a minimum of 30 cc of normal saline, the prepared Platelet-Rich Fibrin (PRF) derived from the patient's blood sample will be placed into the socket. The flap will subsequently be closed using simple sutures with non-absorbable 3-0 silk suture material, which will be removed one week post-surgery. Postoperative care will be including analgesics (Noufen/Ibuprofen as needed for pain), antibiotics (Amoxicillin 500 mg every 8 hours), and 0.2% Chlorhexidine mouthwash every 12 hours for one week. Intervention 2: Control group: In the control group, routine treatment will be performed.Postoperative care will be including analgesics (Noufen/Ibuprofen as needed for pain), antibiotics (Amoxicillin 500 mg every 8 hours), and 0.2% Chlorhexidine mouthwash every 12 hours for one week. No - There is not a plan to make this available Justification or reason for not sharing IPD is No more information available.
public Dr. Mehrdad Shahraki
Faculty of Dentistry., Azadeghan Shargh Ave., Zahedan., Iran.
Zahedan Iran (Islamic Republic of) 9817699693 +98 54 3337 2117 mehrdadsh409@yahoo.com Zahedan University of Medical Sciences scientific Dr.Mehrdad Shahraki
Faculty of Dentistry., Azadeghan Shargh Ave., Zahedan., Iran.
Zahedan Iran (Islamic Republic of) 9817699693 +98 54 3337 2117 mehrdadsh409@yahoo.com Zahedan University of Medical Sciences Iran (Islamic Republic of) The patient's impacted third molar may require surgery, as determined by the dentist. ŮŽAged over 18 years 18 years no limit Both Coagulation disorders Allergy to the anesthetic lidocaine Use of psychotropic and anticoagulant drugs Pregnancy and breastfeeding Treatment - Surgery Treatment - Surgery Intervention group: For patients in the intervention group, following anesthesia administration via injection of the local anesthetic 2% Lidocaine, a full-thickness mucoperiosteal flap will be raised with a distal releasing incision relative to the third molar to achieve access. Following the removal of the impacted tooth and irrigation of the socket with a minimum of 30 cc of normal saline, the prepared Platelet-Rich Fibrin (PRF) derived from the patient's blood sample will be placed into the socket. The flap will subsequently be closed using simple sutures with non-absorbable 3-0 silk suture material, which will be removed one week post-surgery. Postoperative care will be including analgesics (Noufen/Ibuprofen as needed for pain), antibiotics (Amoxicillin 500 mg every 8 hours), and 0.2% Chlorhexidine mouthwash every 12 hours for one week. Control group: In the control group, routine treatment will be performed.Postoperative care will be including analgesics (Noufen/Ibuprofen as needed for pain), antibiotics (Amoxicillin 500 mg every 8 hours), and 0.2% Chlorhexidine mouthwash every 12 hours for one week. Pain. Timepoint: Third, seventh, and twenty-first days after surgery. Method of measurement: Visual Analogue Scale (VAS). Swelling. Timepoint: Before the intervention and on the third, seventh, and twenty-first days after surgery. Method of measurement: The numerical value of the swollen area on the face, measured by vertical and horizontal indicators with calipers. Ecchymosis. Timepoint: Third, seventh, and twenty-first days after surgery. Method of measurement: Skin discoloration caused by blood leaking from blood vessels into the subcutaneous tissues, measured with a caliper. Zahedan University of Medical Sciences Approved 2025-10-05 Ethics Committee of Zahedan University of Medical Sciences Zahedan University of Medical Sciences., Doctor Hesabi square. Khalij Fars Blvd., Zahedan., Iran. Zahedan Sistan-va-Balouchestan Iran (Islamic Republic of)