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IRCT20141228020465N7 IRCT 2025-06-17 Ayatollah Boroujerdi University The effect of aerobic exercise and superfood supplementation on cell death The effect of eight weeks of aerobic training and NBS superfood supplement consumption on factors involved in cell death in men undergoing methadone treatment 2025-05-15 anticipated 60 Complete https://irct.ir/trial/83267 interventional Randomization: Not randomized, Blinding: Double blinded, Placebo: Used, Assignment: Factorial, Purpose: Basic scienece, Blinding description: This study is designed as a double-blind study, so that both participants and researchers will be unaware of the group assignment (supplement/placebo). The supplement and placebo will be provided in identical packaging (in terms of appearance, labeling, and method of administration) and distributed by independent staff of the addiction treatment center who are not involved in other parts of the study. N/A Addiction. Intervention 1: Intervention group 1: Aerobic exercise with supplement intake for 8 weeks. Exercise protocol: First, the subjects will warm up for 10 minutes at an intensity of 50% of maximum heart rate. Aerobic exercise will be performed at an intensity of 75% to 85% of maximum heart rate for 40 minutes, three times a week. Finally, the subjects will cool down for 10 minutes at an intensity of 50% of maximum heart rate. The subjects will receive the NBS Superfood supplement at a rate of 4.5 grams per day orally, dissolved in water, and daily in three equal doses: 1.5 grams in the morning, 1.5 grams in the afternoon, and 1.5 grams in the evening. The supplements will be provided by NBS Superfood (NBS Organic Company, Turkey). Intervention 2: Intervention group 2: Aerobic exercise with placebo for 8 weeks. Subjects will first warm up for 10 minutes at an intensity of 50% HRmax. The aerobic exercise groups will perform high-intensity aerobic exercise (75% to 85% HRmax) for 40 minutes each time three times a week. Finally, subjects will cool down for 10 minutes at an intensity of 50% HRmax. The placebo will be 4.5 grams of potato starch orally per day, dissolved in water, in three equal doses: 1.5 grams in the morning, 1.5 grams in the afternoon, and 1.5 grams in the evening. Intervention 3: Subjects will receive 4.5 grams of NBS Superfood supplement orally, dissolved in water, daily in three equal doses for eight weeks: 1.5 grams in the morning (6 am to 12 pm), 1.5 grams in the afternoon (12 pm to 6 pm) and 1.5 grams in the evening. (from 6 pm to 12 am). The supplements will be provided by NBS Superfood (NBS Organic Company, Turkey). Intervention 4: Control group: The control group will receive only placebo for 8 weeks. They will receive 4.5 grams of potato starch orally, dissolved in water, in three equal doses: 1.5 grams in the morning, 1.5 grams in the afternoon, and 1.5 grams in the evening. They will not do any sports activities and will continue their lifestyle. Undecided - It is not yet known if there will be a plan to make this available Justification or reason for indecision in sharing IPD is Its release schedule is not yet known.
public Fatemeh Omidali
Khorramabad Road-3rd kilometer
Bourojerd Iran (Islamic Republic of) 69199-69737 +98 66 4246 8320 omidali.fatemeh@yahoo.com Ayatollah Boroujerdi University (RA) scientific Negin Kordi
Khorramabad Road-3rd kilometer
Borujerd Iran (Islamic Republic of) 69199-69737 +98 66 4246 8320 K_negin_69@yahoo.com Ayatollah Boroujerdi University (RA) Iran (Islamic Republic of) Negative urine test for morphine, cannabis, and methamphetamine. The need to use methadone maintenance treatment for at least the past three months, Absence of autoimmune diseases, absence of cardiovascular and pulmonary diseases absence of muscle and tendon injuries 25 years 35 years Male Unwillingness to participate in research Being sick P04.4 Newborn (suspected to be) affected by maternal use of drugs of addiction Lifestyle Lifestyle Lifestyle N/A Intervention group 1: Aerobic exercise with supplement intake for 8 weeks. Exercise protocol: First, the subjects will warm up for 10 minutes at an intensity of 50% of maximum heart rate. Aerobic exercise will be performed at an intensity of 75% to 85% of maximum heart rate for 40 minutes, three times a week. Finally, the subjects will cool down for 10 minutes at an intensity of 50% of maximum heart rate. The subjects will receive the NBS Superfood supplement at a rate of 4.5 grams per day orally, dissolved in water, and daily in three equal doses: 1.5 grams in the morning, 1.5 grams in the afternoon, and 1.5 grams in the evening. The supplements will be provided by NBS Superfood (NBS Organic Company, Turkey). Intervention group 2: Aerobic exercise with placebo for 8 weeks. Subjects will first warm up for 10 minutes at an intensity of 50% HRmax. The aerobic exercise groups will perform high-intensity aerobic exercise (75% to 85% HRmax) for 40 minutes each time three times a week. Finally, subjects will cool down for 10 minutes at an intensity of 50% HRmax. The placebo will be 4.5 grams of potato starch orally per day, dissolved in water, in three equal doses: 1.5 grams in the morning, 1.5 grams in the afternoon, and 1.5 grams in the evening. Subjects will receive 4.5 grams of NBS Superfood supplement orally, dissolved in water, daily in three equal doses for eight weeks: 1.5 grams in the morning (6 am to 12 pm), 1.5 grams in the afternoon (12 pm to 6 pm) and 1.5 grams in the evening. (from 6 pm to 12 am). The supplements will be provided by NBS Superfood (NBS Organic Company, Turkey). Control group: The control group will receive only placebo for 8 weeks. They will receive 4.5 grams of potato starch orally, dissolved in water, in three equal doses: 1.5 grams in the morning, 1.5 grams in the afternoon, and 1.5 grams in the evening. They will not do any sports activities and will continue their lifestyle. Ferroptosis. Timepoint: Before the intervention and 8 weeks after the end of the intervention. Method of measurement: Blood sample, serum separation, ELISA kit, use of ELISA reader. Oxidative stress. Timepoint: Before the intervention and 8 weeks after the end of the intervention. Method of measurement: Blood sample, serum separation, ELISA kit, use of ELISA reader. Ayatollah Boroujerdi University Approved 2025-04-20 Research Ethics Committee of the Sports Sciences Research Institute Number 3,Fifth Alley -Mir Emad St.-Ostad Motahari St. Tehran Tehran Iran (Islamic Republic of)