IRCT20250607066102N1 IRCT 2025-07-07 Arak University of Medical Sciences Studying the effect of henna on preventing chemotherapy-induced neuropathy Studying the effectiveness of henna in preventing neuropathy caused by chemotherapy with taxane drugs in cancer patients treated with chemotherapy regimens 2025-06-12 anticipated 50 Complete https://irct.ir/trial/84157 interventional Randomization: Randomized, Blinding: Not blinded, Placebo: Not used, Assignment: Parallel, Purpose: Prevention, Randomization description: In this study, the random permutation block method will be used for randomization. For this purpose, a block of 6 will be used. In each block, three cards will be written with the letter I (Intervention) and three cards with the letter P (Placebo). To hide the cards, they will be placed in an envelope and turned over several times so that their order is not clear. As each participant enters, a card will be selected for him and the selected card will be set aside. This will be done for the next five patients until 6 people are identified. Then, randomization will be done in the same way for the other groups of 6 people to achieve the desired sample size. Some of the selected random blocks of 6 are as follows: PIPIIP, PPIPII, IPPIIP, PIPIPI, IPPIIP, IPIIPP, PIIIPP, IPPIIP, PIIPPI, PPIPII, LPLLPP, LLPLPP, IPPIIP (For example, the random assignment in the 6-patient block PIPIIP is as follows: the first patient is randomly assigned to treatment P, the second patient is randomly assigned to treatment I, the third patient is randomly assigned to treatment P, the fourth patient is randomly assigned to treatment I, the fifth patient is randomly assigned to treatment I, and the sixth patient is randomly assigned to treatment P.). 3 Chemotherapy-induced peripheral neuropathy. Intervention 1: Intervention group: Henna purchased from Atabak Company, Yazd, Iran, is made into 50-gram packets and given to patients, which is mixed with lukewarm water and applied to their hands and feet for 8 hours after each chemotherapy course, which is done every 3 weeks, and 6 chemotherapy courses are done. (Henna is used once every 3 weeks.). Intervention 2: Control group: Do not receive any intervention to reduce chemotherapy-induced peripheral neuropathy. Undecided - It is not yet known if there will be a plan to make this available Justification or reason for indecision in sharing IPD is The release schedule is not yet known.