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IRCT20120215009014N610 IRCT 2026-05-15 Hamedan University of Medical Sciences Effect of coenzyme Q10 supplementation on oxidative stress, inflammation, hematology, liver and kidney profiles in organophosphate poisoned patients Effect of coenzyme Q10 supplementation on oxidative stress, inflammation, hematology, liver and kidney profiles in organophosphate poisoned patients: a single-blind randomized clinical trial 2026-05-31 anticipated 40 Recruiting https://irct.ir/trial/90079 interventional Randomization: Randomized, Blinding: Single blinded, Placebo: Used, Assignment: Parallel, Purpose: Treatment, Randomization description: Random allocation of patients to intervention and control groups by lottery. For this purpose, we prepare two sheets, write "intervention" on one and "control" on the other. Then, with each patient's visit, one of the sheets is randomly taken and the patient is assigned to the intervention or control group, Blinding description: Both the medications and placebos will have the same shape. Consequently, patients will remain unaware of the type of intervention they receive. Therefore, the trial will be conducted as a single-blind study. 3 Organophosphate poisening. Intervention 1: Intervention group: Routine treatment for organophosphate poisoning plus one coenzyme Q10 supplement, 100 mg twice daily, for one week. Intervention 2: Control Group: Routine treatment for organophosphate poisoning plus one placebo capsule (starch) twice daily for one week. Undecided - It is not yet known if there will be a plan to make this available Justification or reason for indecision in sharing IPD is It depends on the situation and the results of the study as well as the approval of the financial supporting organization.
public Dr Freshteh Mehri
School of Medicine, Hamadan University of Medical Sciences, Fahmideh Ave.
Hamadan Iran (Islamic Republic of) 6517838695 +98 81 3838 0572 freshteh_mehri@yahoo.com Hamedan University of Medical Sciences scientific Dr Freshteh Mehri
School of Medicine, Hamadan University of Medical Sciences, Fahmideh Ave.
Hamadan Iran (Islamic Republic of) 6517838695 +98 81 3838 0572 freshteh_mehri@yahoo.com Hamedan University of Medical Sciences Iran (Islamic Republic of) Age of 20 to 40 years, Poisoned with organophosphate 20 years 40 years Both Swallowing disorders T60.0 Toxic effect of organophosphate and carbamate insecticides Treatment - Drugs Placebo Intervention group: Routine treatment for organophosphate poisoning plus one coenzyme Q10 supplement, 100 mg twice daily, for one week Control Group: Routine treatment for organophosphate poisoning plus one placebo capsule (starch) twice daily for one week Lipid peroxidation level. Timepoint: Before the intervention and one week after the intervention. Method of measurement: Using TBA reagent at a wavelength of 532 nm by a spectrophotometer. Total blood antioxidant capacity. Timepoint: Before the intervention and one week after the intervention. Method of measurement: Using TPTZ reagent at a wavelength of 593 nm by a spectrophotometer. Blood thiol group levels. Timepoint: Before the intervention and one week after the intervention. Method of measurement: Using DTNB reagent at a wavelength of 412 nm by a spectrophotometer. Catalase enzyme activity. Timepoint: Before the intervention and one week after the intervention. Method of measurement: Using H₂O₂ reagent and sodium phosphate buffer at a wavelength of 240 nm by a spectrophotometer. CRP level. Timepoint: Before the intervention and one week after the intervention. Method of measurement: By collecting and testing a blood sample. ESR level. Timepoint: Before the intervention and one week after the intervention. Method of measurement: By collecting and testing a blood sample. WBC level. Timepoint: Before the intervention and one week after the intervention. Method of measurement: By collecting and testing a blood sample. RBC level. Timepoint: Before the intervention and one week after the intervention. Method of measurement: By collecting and testing a blood sample. Hemoglobin level. Timepoint: Before the intervention and one week after the intervention. Method of measurement: By collecting and testing a blood sample. Triglyceride level. Timepoint: Before the intervention and one week after the intervention. Method of measurement: By collecting and testing a blood sample. LDL level. Timepoint: Before the intervention and one week after the intervention. Method of measurement: By collecting and testing a blood sample. HDL level. Timepoint: Before the intervention and one week after the intervention. Method of measurement: By collecting and testing a blood sample. Urea level. Timepoint: Before the intervention and one week after the intervention. Method of measurement: By collecting and testing a blood sample. Creatinine level. Timepoint: Before the intervention and one week after the intervention. Method of measurement: By collecting and testing a blood sample. Albumin level. Timepoint: Before the intervention and one week after the intervention. Method of measurement: By collecting and testing a blood sample. Protein level. Timepoint: Before the intervention and one week after the intervention. Method of measurement: By collecting and testing a blood sample. Hamedan University of Medical Sciences Approved 2026-05-09 Ethics Committee of Hamadan University of Medical Sciences Vice-chancellor for Research and Technology, Hamadan University of Medical Sciences, Fahmideh Avev Hamadan Hamadan Iran (Islamic Republic of)