]>
IRCT20200305046700N19 IRCT 2026-10-10 Tehran University of Medical Sciences Comparison of Nylon and Monocryl Sutures for Skin Closure Following Hip Arthroplasty Comparison of Nylon and Monocryl Sutures for Skin Closure and Their Effects on Wound Healing Outcomes in Patients Undergoing Hip Arthroplasty: A Randomized Clinical Trial 2026-11-06 anticipated 126 Recruiting https://irct.ir/trial/91464 interventional Randomization: Randomized, Blinding: Double blinded, Placebo: Not used, Assignment: Parallel, Purpose: Treatment, Randomization description: Patients will be randomly allocated in a 1:1 ratio to either the nylon or Monocryl suture group. Randomization will be performed using the Sealed Envelope online randomization service. A computer-generated permuted block randomization sequence with variable block sizes of 4 and 6 will be used. The randomization sequence will be generated before recruitment and will not be accessible to investigators responsible for patient enrollment. For allocation concealment, each assignment will be associated with a sequentially numbered, sealed, opaque card. After confirming eligibility and enrolling the patient, the study secretary will open the next card in sequence and communicate the assigned group to the surgeon immediately before surgery. Thus, the treatment allocation will remain concealed until the patient has been enrolled and randomized, Blinding description: Patients will be blinded to the type of suture used and will not be informed of their group allocation. On the day of surgery, the patient’s group allocation will be communicated to the surgeon by the study secretary. Postoperative data from patients in groups A and B will be collected and recorded by the study assistants. The data will be coded without identifying the suture type or treatment group and will subsequently be provided to the data analyst. The analyst will remain blinded to group allocation and suture type until completion of the statistical analysis. N/A Total Hip Arthroplasty. Intervention 1: Intervention group: Group 1 (Nylon Suture): In this group, the wounds will be closed using nylon sutures with interrupted subcutaneous stitches. Intervention 2: Intervention group: Group 2 (Monocryl Suture): In this group, the wounds will be closed using Monocryl sutures with interrupted subcutaneous stitches. No - There is not a plan to make this available Justification or reason for not sharing IPD is There is not a plan to make this available
public Mohammadreza Razzaghof
Joint Reconstruction Research Center, Imam Khomeini Hospital Complex, East Baqerkhan Street, North Chamran Highway
Tehran Iran (Islamic Republic of) 1419733141 +98 21 6658 1586 m.razzaghof@gmail.com Tehran University of Medical Sciences scientific Mohammadreza Razzaghof
Joint Reconstruction Research Center, Imam Khomeini Hospital Complex, East Baqerkhan Street, North Chamran Highway
Tehran Iran (Islamic Republic of) 1419733141 +98 21 6658 1586 m.razzaghof@gmail.com Tehran University of Medical Sciences Iran (Islamic Republic of) Patients requiring hip replacement surgery, aged 18 to 85 years, confirmation of patient awareness regarding the study and provision of informed consent. 18 years 85 years Both Patients with a history of prior surgery in the target joint area patients with inflammatory joint diseases patients who smoke or consume alcohol patients with hypoalbuminemia or severe anemia patients unable to provide informed consent Z96.6 Presence of orthopedic joint implants N/A N/A Intervention group: Group 1 (Nylon Suture): In this group, the wounds will be closed using nylon sutures with interrupted subcutaneous stitches. Intervention group: Group 2 (Monocryl Suture): In this group, the wounds will be closed using Monocryl sutures with interrupted subcutaneous stitches. Wound pain intensity. Timepoint: Days 5 and 14, and weeks 6 and 12, and months 3 and 6 after surgery. Method of measurement: A numerical scale ranging from 0 to 10, on which the patient self-reports the intensity of pain. Wound cosmetics. Timepoint: Days 5 and 14, and weeks 6 and 12, and months 3 and 6 after surgery. Method of measurement: POSAS (Patient and Observer Scar Assessment Scale), assessed by both the patient and the observer. Wound complications. Timepoint: Days 5 and 14, and weeks 6 and 12, and months 3 and 6 after surgery. Method of measurement: Clinical assessment and reporting by both the patient and the physician. Wound healing time. Timepoint: Days 5 and 14, and weeks 6 and 12, and months 3 and 6 after surgery. Method of measurement: Assessment of the time required for complete wound healing. Tehran University of Medical Sciences Approved 2026-06-02 Ethics committee of Tehran University of Medical Sciences Tehran University of Medical Sciences, International Campus, Office of Vice-President for Educational Affairs, Number 25, Hojat Dost St., Felestin St., Keshavarz Blvd., Tehran , Iran. Tehran Tehran Iran (Islamic Republic of)