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IRCT20260203068755N2 IRCT 2026-08-03 Shahid Beheshti University of Medical Sciences Effect of Simultaneous Intravenous Fentanyl and Morphine on Pain Relief and Recovery After Lumbar Spine Surgery Evaluation of pain control, rate of awakening, and airway quality after simultaneous intravenous administration of fentanyl (5 micrograms per kilogram of body weight) and morphine (5 mg) in posterior spinal fusion surgery patients at Akhtar hospital: A case series study 2026-09-06 anticipated 60 Complete https://irct.ir/trial/92096 interventional Randomization: Not randomized, Blinding: Not blinded, Placebo: Not used, Assignment: Single, Purpose: Treatment. N/A Lumbar degenerative spine disorders requiring elective posterior lumbar spinal fusion surgery. Intervention group: Participants will receive intravenous fentanyl at a dose of 5 micrograms per kilogram of body weight and intravenous morphine at a fixed dose of 5 milligrams simultaneously during induction of general anesthesia. General anesthesia will be induced with propofol and maintained with sevoflurane according to the hospital's standard anesthetic protocol. Standard postoperative analgesia and prophylaxis for postoperative nausea and vomiting will be provided according to institutional practice.. Yes - There is a plan to make this available What will be shared: Data regarding anesthesia and outcomes measurements will be available. When: After data collection completion To whom: Other researchers Conditions: belonging to academic institution Where to obtain: researcher's personal email shayankamalfar@sbmu.ac.ir How to obtain: requesting by email Comments:
public Shayan Kamalfar
Shahid Chamran Highway- Evin- next to Taleghani Hospital- Medical School- third floor
Tehran Iran (Islamic Republic of) 1983963113 +98 922 769 5794 shayankamalfar@sbmu.ac.ir Shahid Beheshti University of Medical Sciences scientific ُShayan Kamalfar
Shahid Chamran Highway- Evin- next to Taleghani Hospital- Medical School- third floor
Tehran Iran (Islamic Republic of) 1983963113 +98 21 2303 1290 shayankamalfar@sbmu.ac.ir Shahid Beheshti University of Medical Sciences Iran (Islamic Republic of) Adults aged 18 to 65 years American Society of Anesthesiologists (ASA) physical status I–III. Scheduled for elective posterior lumbar spinal fusion under general anesthesia. Body weight between 60 and 100 kg. Able to provide written informed consent. 18 years 65 years Both Known allergy or hypersensitivity to fentanyl, morphine, or other opioids. Severe hepatic impairment (Child–Pugh class C). Severe renal impairment (eGFR <30 mL/min/1.73 m²). Chronic opioid use or opioid dependence. History of substance abuse. Severe chronic respiratory disease (such as chronic obstructive pulmonary disease). Pregnancy or breastfeeding. Inability to provide informed consent. M00-M99 Diseases of the musculoskeletal system and connective tissue Treatment - Drugs Intervention group: Participants will receive intravenous fentanyl at a dose of 5 micrograms per kilogram of body weight and intravenous morphine at a fixed dose of 5 milligrams simultaneously during induction of general anesthesia. General anesthesia will be induced with propofol and maintained with sevoflurane according to the hospital's standard anesthetic protocol. Standard postoperative analgesia and prophylaxis for postoperative nausea and vomiting will be provided according to institutional practice. Postoperative pain intensity measured using the Visual Analogue Scale. Timepoint: At admission to the post anesthesia care unit, and at 2, 4, 6, 12, and 24 hours after surgery. Method of measurement: Pain intensity will be assessed using the ten centimeter Visual Analogue Scale, with scores ranging from zero, indicating no pain, to ten, indicating the worst imaginable pain. Shahid Beheshti University of Medical Sciences Approved 2026-06-22 School of Medicine - Shahid Beheshti University of Medical Sciences (Research Ethics Committee) Shahid Chamran Highway- Evin- next to Taleghani Hospital- Medical School- third floor Tehran Tehran Iran (Islamic Republic of)