IRCT20251121068066N14 IRCT 2026-08-15 Shahid Beheshti University of Medical Sciences Evaluation of the Effect of Alternating Tadalafil and Tamsulosin Compared with Tamsulosin Alone Comparison of the Effects of Alternate-Day Tadalafil and Tamsulosin Use with Daily Tamsulosin Use on Lower Urinary Tract Symptoms and Sexual Dysfunction in Men with Benign Prostatic Hyperplasia 2026-09-11 anticipated 62 Complete https://irct.ir/trial/92278 interventional Randomization: Randomized, Blinding: Not blinded, Placebo: Not used, Assignment: Parallel, Purpose: Treatment, Randomization description: Participants were recruited using convenience sampling. Treatment codes were prepared and placed in blinded packages before the start of the study. After eligibility screening and obtaining written informed consent, participants were sequentially entered into the predetermined randomization sequence according to their order of enrollment. Participants were randomly allocated in a 1:1 ratio to the intervention or control group using block randomization with a block size of four. The corresponding treatment assignment was placed in a sequentially numbered, opaque, sealed envelope and will be performed by an independent urologist who is not involved in the research team. 2 Benign Prostatic Hyperplasia; BPH. Intervention 1: Intervention group 1:Participants will receive 0.4 mg of tamsulosin from Actover brand daily for 12 weeks. Intervention 2: Intervention group 2: Participants will receive an alternating regimen of tadalafil 5 mg (Mofid) and tamsulosin 0.4 mg (Actover) on alternate days for 12 weeks, such that one medication (tadalafil or tamsulosin) is taken each day. Undecided - It is not yet known if there will be a plan to make this available Justification or reason for indecision in sharing IPD is No more information available.