IRCT20260531069588N1 IRCT 2026-11-04 Mazandaran University of Medical Sciences Comparison of the effects of hesperidin and nystatin mouthwashes in treating mucosal inflammation The effect of Hesperidin mouthwash in comparison with nystatin on patients with Denture Stomatitis: A Clinical Trial 2026-11-22 anticipated 24 Pending https://irct.ir/trial/94518 interventional Randomization: Randomized, Blinding: Double blinded, Placebo: Not used, Assignment: Parallel, Purpose: Treatment, Randomization description: Simple randomization will be performed, with the individual patient as the unit of randomization. A random number between zero and one will be generated for each eligible patient using the RAND function in Microsoft Excel. Patients assigned a number below 0.5 will receive hesperidin mouthwash, whereas those assigned a number of 0.5 or above will receive nystatin mouthwash, Blinding description: Participants, treating clinicians, and examiners responsible for outcome assessment will be unaware of participants’ group allocation and the mouthwash received. Hesperidin and nystatin mouthwashes will be supplied in containers with similar shape, size, and color. The mouthwashes will be dispensed by personnel other than the examiner so that the person examining and measuring the lesions remains unaware of the assigned treatment. 2 Denture stomatitis type II. Intervention 1: Intervention group: Hesperidin mouthwash, 20 milliliters per application, three times daily for two weeks. Patients will retain the mouthwash in their mouth for one minute and avoid eating or drinking for one hour afterward. Intervention 2: Control group: Nystatin mouthwash at a concentration of 100,000 units per milliliter, 20 milliliters per application, three times daily for two weeks. Patients will retain the mouthwash in their mouth for one minute and avoid eating or drinking for one hour afterward. No - There is not a plan to make this available Justification or reason for not sharing IPD is No further information is available.