Introduction: nausea and vomiting caused by chemotherapy is the most important complication and discomfort for cancer' patients. Nausea and vomiting causes physiologic and electrolyte disorders, Immunity system changes, Nutrition disorders and rupture of esophagus and effect in the quality of life and continuing of patient̉s treatment. Ginger is one vegetable and effective drug for the treatment of nausea and vomiting and doesn’t have any special side effects and some countries use it tor produce antiemetic drugs. Objective : This study aims to determine the effect of ginger on the severity of chemotherapy induced nausea and vomiting in cancer patients. Material and Methods: This study is a randomized, cross-over, double – blinded, clinical trial, done on 44 cancer patients undergoing chemotherapy. In the first cycle of the study, Patients randomly assigned by four block random allocation to receive one of the antiemetic regimen (regimen A (routine + 1 gr ginger ) and regimen B(routine +1gr Placebos). In the next cycle of chemotherapy , 28 days after the previous cycle another regimen (A or B ) administrated together with chemotherapy drugs. The severity of the nausea and vomiting were measured in 4h (1,2,3,4 (hours) after second dose and at the end of the 24h after receiving first dose by using of VAS and kortila tools . Key word: Drug Therapy/ Ginger/ Nausea/ Neoplasms/ Oncologic Nursing/ Vomiting