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Effect of Silymarin on Non Alcoholic Steatohepatitis
The aim of this clinical trial is to study the effect of Silymarin on non alcoholic steatohepatitis in patients with nonalcoholic fatty liver disease. Fifty patients will be included. They are older than 20 years with nonalcoholic-fatty liver disease and liver enzymes> 50 and proportion of ALT/ AST> 1. The fatty liver will be recognized by sonography. Exclusion criteria are using drugs that affect liver tests during the last 2 months, viral hepatitis, hemochromatosis, autoimmune hepatitis, cirrhosis, diabetes mellitus, alcohol dependency, pregnancy, breast feeding, and infectious diseases. Intervention group will be administrated 140 mg of Silymarin BID during 6 month and control group will be given placebo. Liver enzymes and recovery of liver markers in sonography will be assessed after 6 months of treatment course.
IRCTID: IRCT138805172308N1
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