The purpose of present study was to examine the preventive effects of purgative manna on neonate’s icter. It was a double blind clinical Trial study conducted among neonates who was born on Be’sat Hospital, Sanandaj, Iran. The sample size was 70 neonates in each group. . An inclusion criterion was being full term neonate and exclusion criteria were congenital anomalies and icter in day 1. Patients were divided into two groups using blocked randomization. Twenty four hours after birth, for three days, five drops of oral purgative manna drop (BiliNaster produced by Sobhan Co.) was given to intervention group three times a day, and placebo, produced by the same company, was given to infants in control group. Bilirobin and clinical evaluation for determining icter were measured during the third to fifth days.