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To study preventive effect of disinfectant solutions (alcohol, povidone - Iodine, and chlorhexidine - alcohol) on catheter insertion places in 123 patients who need IV line at internal wards of Beasat hospital, Sanandaj, Iran. Patients were randomly divided into 3 groups: alcohol, povidone - Iodine, and chlorhexidine - alcohol group. Catheter entry points were evaluated for phlebitis after 48 to 72 hours.