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The purpose of this study was to compare Amitriptyline versus Carbamazepine in the treatment of painful diabetic neuropathy. A total of 60 patients with type 2 diabetes were randomly assigned to receive Amitriptyline, 50 mg/d or Carbamazepine, 200mg, TDS, for six weeks, in a double blind trial. Intensity of pain was evaluated based on brief pain inventory before the study and six weeks after administration of drugs.