Background and introduction: A recent report published by the World Health Organization on the importance of chronic diseases including hypertension as a deterrent factor of countries access to appropriate health status has been emphasized. Objectives: Determines the effects of reform temperament (Mizaj) and wet-cupping for treating persistent hypertension. Inclusion criteria included: Hypertension; age 30-60 years; Not having a history of chronic disease such as diabetes and kidney; to do not have reform temperament or wet-cupping for 1 years ago. Exclusion criteria included: Experience unpleasant and serious accidents, such as relatives died in the past 6 months; females become pregnant during the study; current treatment with other complementary treatments. In total, 189patients aged 30-60 years with hypertension; 126were randomly assigned to experimental (63patients in wet-cupping and 63patients in reform temperament) and 63to the control group. Patients in the experimental group were offered usual care and also reform temperament or wet-cupping and the control group received usual care. Three outcomes assessed at baseline and again 45 days following start intervention.