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The aim of this study was to investigate the effect of Progressive muscle Relaxation training on anxiety of the Schizophrenia patient that refers to Sina hospitals in Jooneghan. 46 Schizophrenia patients were randomly assigned to participate in a Progressive muscle Relaxation program for three months that include 90 sessions and each session include 45 minutes or receive routine cares. Primary outcome was anxiety and secondary outcome was the situation of patients.