The aim of this double blind study the therapeutic effects of medicinal products with Hypericum is an antidepressant. 40 depressed patients referred to psychiatric clinic with a diagnosis of depression based on TR DSM-IV criteria for diagnosis are studied. Patients randomly divided into two groups and a group of tricyclic antidepressants in treating depression and a range of moderate Hypericum tablets three times daily for 6 weeks and another group tricyclic antidepressants in the range of moderate depression and a number placebo tablets three times daily for 6 weeks received. Before intervention and at three and six weeks with a severely depressed therapist measured by Beck Depression Inventory and the two groups are compared.