Aim: The purpose of this study was Determine and Comparison the effects of combination extract Fennel and Vitamin E with Ibuprofen on the intensity in primary dysmenorrhoea in the Tabriz city students, 2007-2009. Mateial&Methods: This study was done by double-blinded Quasi Experimental Research method. 68 students from Medical and Tabriz Universities who were living in the dormitory, and suffering from primary dysmenorrhea and had condition of study were separated randomly in two groups ( N= 34). Inclusion criteria: primary dysmenorrhea with a sum score of Visual Analogue Scale 3.1- 9, Students with cyclic menstrual bleeding that cycle length between 25 and 35 days and no amenorrheic cycles or cycles without withdrawal bleeding during the last 3 months prior to first visit... Exclusion criteria: Known or suspected NSAIDs allergy or suspected contraindication to herbal remedies... Then the samples recorded Intensity pain of primary dysmenorrhea without medication in the first month; and these groups used "combining extract Fennel and Vitamin E" and Ibuprofen cross-over form in the two mouths. we used VAS tool for defineing the intensity of the pain. Data analyzing was done by using Spss 14 win .