This research is a single-blind randomized controlled clinical trial study. The sample size will be 120 children between the ages of 8 and 12, who randomly divided to experimental and placebo groups. Subjects shouldn't have prior experience of acupressure and anticipated survival will be more than 3 months and Patients will excluded if they had low platelet count (<50,000); suffered from a bleeding disorder (e.g. hemophilia). Routine care was administered to the both groups. at pre-intervention, in the second day of chemotherapy, nausea and fatigue intensity will be measure by Visual Analogue Scales Then the intervention (finger acupressure) will apply for 3 minutes on P6 and ST36 (true points) in the experimental group, and on LI12 and SI3 (sham points) in the placebo group. We will evaluate the symptoms of nausea and fatigue intensity immediately and one hour after the intervention. Then the variable of nausea/vomiting and fatigue will measure at 12 and 24 hours after the intervention by the instruments of Adapted Rhodes Index of Nausea and Vomiting for Pediatrics by Child (ARINVc) and Fatigue Scale Child (FSC).