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The objective of this clinical trial study was to investigate the effect of Yoga on multiple sclerosis. A total of 60 patients with MS from Kohgiloyeh and Boirahmad province were randomly assigned into intervention or control groups. The patients in the intervention groups received Yoga therapy for a period of 3 months, eight 1-1.5 hour sessions per month. Severity of fatigue and quality of life were measured by using a standard questionnaire and MSQoL-54 questionnaire, respectively, and compared between the groups.