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The purpose of this randomized, double-blind clinical trial without placebo is to compare the effect of ondanstron and dexametasone on nausea and vomiting after laparascopic cystectomy. In this study, 150 patients undergoing laparoscopic cholecystectomy operation between 65-20 years of age who meet the study inclusion and exclusion criteria are randomly assigned in one of the three intervention groups to receive ondansetron or dexamethasone, or combination of them immediately before they receive general anesthesia and the presence or absence of nausea and vomiting in the three groups will be compared.