Multiple sclerosis (MS) is a chronic, progressive neurological disease that results in a set of environmental factors, genetic and autoimmune occurs. This study investigated the effect of acupressure in reducing fatigue and pain that patients with MS. METHODS: A sample of 100 women (18-40 years) of the MS Society in Tehran have inclusion criteria (female, they have a week of pain, fatigue are mentioned, the use of lack of acupressure) are selected. Patients randomized in the acupressure group (n = 50) and controls (n = 50). Pain is measured with visual analog scale and fatigue is measured with FSS questionnaire.Interventions in this study is to educate patients for intervention.In groups of three points LI4, SP6, ST36, each for two minutes on each side of the body three times a day for two weeks to do by themselves. In control group instead of just pushing the points they are touched.The FSS questionnaire and visual analog scale of pain completed once before the first intervention, immediately after the intervention, two weeks and four weeks after they completed the intervention. Patients who do not want to do and don't a quarter days are excluded.