Study aim: The aim of this study was to compared effects of Royal jelly with Omega 3 on fatigue and quality of life of multiple sclerosis patients Design: This study was a double-blind, controlled trial, 33 patients with MS were assigned in each group.For randomization, the permuted block randomization will be used with quadruple blocks, In order to apply the concealment in the randomization process, unique codes, which is generated by the software, will be used on the drug boxes. Settings and conduct: All patients referred to Imam Golestan Hospital of Ahvaz, Iran, were assigned randomly in one of the treatment regimens for 4 weeks, Participants/Inclusion and exclusion criteria: Inclusion criteria: MS patients have fatigue; No other neurological disease; No Diseases like diabetes and autoimmune diseases; No new attack in the last month Exclusion criteria: Emergence of drug side effects; New disease attack; Do not take medicine for one week; Pregnancy Intervention groups: Intervention group: Interferon (main treatment) with Omega-3 capsules (1 g daily) for one month Intervention group: Intervention group: Interferon (main treatment) with Royal jelly capsules (1 g daily) for one month Main outcome variables: MFIS questionnaire MSQL-54 questionnaire Blood parameters