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Study aim: To comparison the number of ovarian antral follicles in the group receiving fennel capsules and the control group. To comparison AMH levels in the group receiving fennel capsules and the control group. Design: Clinical trial with control group, triple blind, randomized, parallel groups, phase 3 on 60 patients. Randomizer software is used for randomization. Settings and conduct: In this three-blind clinical trial (participants, researcher and data analyst) patients referred to Al-Zahra infertility clinic of Tabriz underwent trans vaginal ultrasound of the ovary on the third day of menstrual cycle once before the start of the interventionto check the number of antral follicles. Antimullerin hormone level will be assessed on the same day by one expert. Drug or placebo, is placed in numbered opaque glasses, and in this way, participants will be placed in groups. During the intervention period the participants will receive three fennel capsules with a dose of 30 mg or three placebos daily. will be taken daily orally. At the end of the second month of the intervention, on the third day of menstruation, AMH tests and trans-vaginal ultrasound will be performed on the participants again. Participants/Inclusion and exclusion criteria: Inclusion criteria: 1) Antimullerian hormone>1 , or reduction of ovarian follicular reserve by transvaginal ultrasound (reduction of antral follicles less than 6 in each ovary) 2) The presence of menstrual cycles 3) Having both ovaries Exclusion criteria: 1) Using alcohol and cigarrete 2) Obesity, BMI >30 Intervention groups: Intervention group: 30 mg fennel capsules made by Barnj Essens Company will be used. Control group: They will receive placebo in the form of 60 oral gelatin capsules. Main outcome variables: Antimullerian hormone levels, number of ovarian antral follicles
IRCTID: IRCT20111219008459N15
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