This interventional study is double blind clinical trial that examines the acupressure effect on pain and anxiety in patients undergoing bone marrow biopsy. The participants will be randomized into three groups of 30 patients (intervention, control and placebo). Half-hour before biopsy, all patients complete Spielberger anxiety questionnaire and the vital signs will be recorded by co-researcher. In the intervention group, the acupressure will be performed using researcher’s thumb on the He7 (anti-anxiety point) and the LI4 (anti-pain point). In the placebo group, the acupressure method is the same but in the different points without any anti-anxiety and anti-pain effect. No procedure will be performed in the control group. The anxiety and vital signs will be recorded again during and immediately after the biopsy. The pain will be measured using a visual analogue scale (VAS) after the biopsy was taken.