This study examined the effect of Ginger on some inflammatory and Immunity factors in patients with active RA referring to shariaty Hospital. In a randomized, double-blind, placebo -controlled clinical trial, 70 patients ,age between 18-69 years old with Active RA after Rheumatologist examination and filling personal, medical and food questionnaires will be enrolled in the study. They will be divided in 2 groups (35 numbers in each group) including: 1- Ginger (case) 2-Placebo (control) randomly. Patients in case group will receive 1500 mg of powdered Ginger daily (by two 750 mg capsules) for 3 months and control patients will receive 1500 mg Wheat flour daily (by two 750mg capsules) , one 750 mg capsule before lunch and one before dinner for 3 months. Placebo capsules are completely similar to cases one and will divide randomly between Patients. Patients will be control weekly by calling and in the end of each month by visiting. before and After the 3 months intervention period this test for comparing two groups will be done: DAS28, ESR, CRP, ILIβ, TNFα, IL17, IL2, IL4, IL10 in two groups will be compared.