Study aim: Evaluation of the effect of administration of melatonin on the frequency and severity of headache in menstrual migraine patients compared with administration of non-steroidal anti-inflammatory drugs Design: A double-blind, randomized, controlled trial Settings and conduct: The study was conducted at Imam Khomeini Hospital's neurology clinic on patients with menstrual migraine. The patients were divided into two groups and assigned to one group of naproxen and the other group received melatonin and at the beginning and one month later and three months after the severity And frequency headache were studied. The patients and the person who completed the questionnaire and analyzed the blind. Participants/Inclusion and exclusion criteria: Women with menstrual migraine who are not pregnant and who are not suffering from other primary headaches and chronic headaches Intervention groups: Administration of melatonin and its efficacy compared with administration of naproxen and evaluation of the effects of administration of melatonin Main outcome variables: Effect of Melatonin as Prophylaxis and Study of Complications of Melatonin Administration and Effectiveness in Sleep Disorders in Patients