Study aim: Comparison of interactive psycho-educational interventions via social networks with placebo on anxiety and self-efficacy of patients infected with COVID-19 and lived in home quarantine Design: A clinical trial with control group, parallel group randomized trial and single blinded Settings and conduct: The setting is Shiraz city. In this study, a person who collects the outcomes of the study, as well as a statistician and health care provider, will be blind until the end of the study and completion of the data analysis and reporting. Participants/Inclusion and exclusion criteria: The inclusion criteria of this study are aging ≥ 18 years, having diagnosis of COVID-19, being able to use cell phone and having access to Internet, being at home quarantine at least 48 hours, having need to be in home quarantine at least one week. Patients who are admitted in hospital, are died, have severe symptoms that not being able to speak, perform exercise or complete the questionnaires, have previous experience of home quarantine and have psychological diseases such as psychosis and dementia are excluded. Intervention groups: The patients in the intervention group are enrolled in a WhatsApp group. They would receive numerous videos, audio files, and educational texts regarding mental health, coping strategies, positive thinking, hope, spiritual well-being, and some enjoyable activities such as relaxation music. Other psychological interventions are included encouraging the patients to apply trained psychological techniques, and sharing good memories of their lives, gratitude and thanking God, and expressing their positive abilities in a variety of areas in the group. Every day, a researcher is contacted to the subjects and approved they would continued and followed as order. Main outcome variables: self-efficacy and anxiety