The aim of this study was to investigate the effect of yoga and exercise on quality of life in patients with multiple sclerosis. This was a quasi-experimental study that patients were randomized into three Yoga, exercise and control groups. In this study, 61 patients (20 in the control group, 20 in yoga group, and 21 in exercise group) were participated. Inclusion criteria was tendency to participate in the study, speaking ability, membership in multiple sclerosis society and ability of movement and doing daily activity. Exclusion criteria was death or patients non-cooperation.The exercise and yoga sessions performed twice a week and each session was held for 30 minutes for 12 weeks. The data was gathered using SF36 quality of life Questionnaire at the base and the end of study.