This study is a triple blind cilinical trial and randomized has conducted with the purpose of determination and comparison of the effect of honey vaginal cream and combination of honey and yoghurt vaginal cream for the treatment of vulvovaginal candidiasis in women whom referred to sari health medical center. In this cilinical trial,105 women with known candidiasis will be randomly allocated into three groups. Each group will be 35 person. Drugs consist of: combination of honey and yoghurt , honey and clotrimazole vaginal creams . To hide the allocation, the creams will be prepared in Armaghan teb pharmacy laboratory medicine of tehran and they will be put in quit similar packages and will be available to researcher with codes A,B,C . Data collection was accomplished demographic information questionnaire and clinical performance checklist. Patients will be randomly allocated in groups A,B,C and each group will receive a vaginal cream with the same code similar to the group. The creams are using intra vaginal one applicator every night for 7 nights. They will be recommended to comply with health issues and do not use douching, other vaginal drugs and also herbal and systemic drugs during study period. We will ask participants to come back 7 days and 14 days after initiation of treatment for evaluation of treatment and relapse, respectively. The infection diagnosis and evaluation of treatment and relapse will be based on clinical symptoms, assessment of vaginal pH, direct observation and culture .