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Study aim: The aim of the present study was to evaluate the effectiveness of Propolis gel under Coe-Pack on gingival on Gingival Healing Indices after periodontal flap surgery. Design: Clinical trials have a control group, two-way blind, easily randomized, phase 3 on 18 patients. The flip coin method was used to randomize each side of the mouth Settings and conduct: In the specialized department of the Faculty of Dentistry, University of Isfahan. Selection of 20 patients by easy sampling method. Everyone is blind except the clinical caregiver. Select the patient's first position using the flip coin method and place in group A. also, gel and placebo have A and B labels Participants/Inclusion and exclusion criteria: Entry requirements: Patients with moderate to severe chronic Periodontitis require two side or whole mouth periodontal flap surgery that is systemically healthy The same type of flap on both sides in each person Age over 18 years Pelaque index Less than or equal to 1 after health education No contraindications for surgery No need for prophylactic Antibiotics Do not take Corticosteroids or Hormones for the past two months Having acceptable cooperation Conditions of non-entry: Smoking Pregnancy Taking anti-inflammatory drugs or Antibiotics Existence of systemic disease Pelaque index 2 or 3 after health education Need to cut more than 2 mm of bone Lack of cooperation and patient satisfaction Intervention groups: Treatment group: after surgery, use 20% propolis gel, which is made by Propolis Manufacturing Company (Green Plants of Life Company) under the Coe Pack dressing(GC America Inc), and then mix the Coe Pack thoroughly and apply it on the surgery site Control group: after periodontal flap surgery, we place the placebo gel and then put the Coe Pack dressing( GC America inc) on the desired place Main outcome variables: Pain index, plaque index, papillary bleeding index, healing index
IRCTID: IRCT20150210021029N2
  1. The comparison of Diplen LX membrane and Coe-pack usage from the patient preference point of view and on the pain and wound healing after the periodontal flap surgery in patients with moderate to severe periodontitis
  2. Clinical trial of comparison the effect of the propolis extract in combination with dressing without eugenol (Coe-Packtm) and Coe Packtm dressing in wound healing among patients undergoing crown lengthening surgery
  3. Evaluation the effect of non-eugenol periodontal dressing (Coe-Pak) on pain and wound healing after crown lengthening surgery
  4. Effect of using Aloe vera gel on wound healing following periodontal flap surgery (clinical trial)
  5. Clinical evaluation of the efficacy of nano-emul gel of Atorvastatin on the healing of wounds after periodontal flap surgery (double-blinded randomized clinical trial)
  6. Clinical Evaluation of Effects of Aloe Vera Gel Local Application As an Adjunct to Scaling and Root Planning in Patients with Chronic Periodontitis
  7. Clinical Trial Study of Coe-Pak Dressing effect on Pain and Microbial Contamination of Suture after Surgery in Patients with Chronic Periodontitis
  8. Design and formulation of periodontal dressing and invivo assesment incompare with Coe-pak
  9. The Eeffect of Topical Erythropoietin on Palatal Wound Healing Subsequent to Free Gingival Graft in patients with insufficient keratinized gingiva. Evaluation of Topical Erythropoietin Application on the Healing Outcome of Gingival Graft Recipient Site; A Randomized Controlled Clinical Trial.
  10. Efficacy of Cyanoacrylate Tissue Adhesive (GLUBRAN® Tiss 2) Versus CoePak Periodontal Dressing on Palatal Wound After Following Free Gingival Graft Harvesting: A Randomized Double-Blind Clinical Trial
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