Study aim: The Aim of Study Will be to Investigate the Effectiveness of Cognitive- Behavioral Group Therapy (CBGT) on Anxiety, Self- Esteem, Quality of Life, Pain Self-Efficacy and Hope in Patients with Multiple Sclerosis (MS). Design: In an Experimental Study With a Pretest-Posttest Control Group Design, 20 Patients With (MS) Will be Selected Through Convenience Sampling Method. Settings and conduct: The Society for the Protection of Patients With Multiple Sclerosis in Mashhad and Will be Assign to Two Experimental and Control Groups, Each Contain 10 Individuals. Participants/Inclusion and exclusion criteria: The inclusion criteria: Aged between 20 to 50 years, having at least a high school diploma, Willingness to participate in the study and being randomly into one of the study groups, Diagnosis of MS by a neurologist, Anxiety disorder based on Beck Anxiety Inventory with a score higher than 26,Completing the agreement form. The exclusion criteria: Having physical and mental diseases, Receiving intrudent pharmacological and non pharmacological treatments, Patients with any serious psychological disorders (including psychotic disorders or active substance abuse), Having a neurological disorder other than MS, Education less than fifth elementary. Intervention groups: Experimental Group: The Intervention group will attend Cognitive- Behavioral Group Therapy Sessions for 6 Weeks (10 sessions of two hour). In General, the Treatment Plan for this Group Will be to at Assess Previous Session Homework, Teaching a New Technique and Giving Homework for Future Session. Control group:The control group simultaneously (10 two-hour sessions for 10 weeks) will continue Center’s usual care plan of the group. Main outcome variables: Increase Self- Esteem, Hope, Pain Self-Efficacy, Improvement of Quality of Life and Decreased Anxiety