The aim of this double blind clinical trial study is to compaire the effect of 0.5% Minoxidil cream with 2% Diltiazem cream on the patients suffering from chronic anal fissure coming to Imam khomeyni hospital,in Sari,in1393.patients suffering from Diabetes ,Hypertentsion ,cardiovascular disease and also those consuming Anti hypertensive drugs will be excluded .The total sample which includes110 patients,will be divided into two groups based on random-number table.The sampling will be undertaken over eight weeks.Each patient will be apply either Cream A OR B twice a day for two weeks.All of them will be reffer to the Office or Surgical clinic after one and also two months afterwards. Then they will be examine by the medical team for evaluating of Wound Healing , Bleeding,Pain , Itching and Dizziness.afterwards, the collected data including the effects of the two drugs on considered Variables will be located in corresponding columns to be compared later on.