Study aim: Determining the comparative effect of two methods of relaxation and meditation on serum levels of IL-2, TNF-α, IL-17A and IL-23 cytokines in patients with coronary artery disease referred to the outpatient cardiology clinic in 2018 Design: A clinical trial study has a control group with parallel, one-blind, and randomized groups. Settings and conduct: Patients are selected from patients with coronary artery disease referred to the outpatient clinic of Rafsanjan University of Medical Sciences. After obtaining informed consent, individuals will be randomly assigned to the above groups. Intervention for relaxation and meditation is done for each of the groups; Before the study begins and three months after the start of the study, the blood sample is taken from the patient. Participants/Inclusion and exclusion criteria: Inclusion criteria: known coronary artery disease (based on medical records), history of hospitalization in the CCU, willingness to participate in the study.Exclusion criteria: History of mental illness or using psychiatric drugs , History of heart failure, َThe history of autoimmune diseases, allergies and immune-related diseases. Intervention groups: For a group, meditation intervention is performed and relaxation intervention is performed for a group. The control group receives routine care. Main outcome variables: serum levels of IL-2, TNF-α, IL-17A and IL-23 cytokines in patients with coronary artery disease