Study aim: Determining the Comparison of the effects of relaxation and meditation techniques on serum levels of IL-10, TGF-β, IL-6 and IFN-γ in the patients with Coronary Artery Disease Design: The research sample consisted of 90 participants.This clinical trial study has 3 groups with parallel and randomized groups. Settings and conduct: Patients are selected from patients with coronary artery disease referred to the outpatient clinic of Rafsanjan University of Medical Sciences. After obtaining informed consent, individuals will be randomly assigned to the above groups. Intervention for relaxation and meditation is done for each of the groups; Before the study begins and three months after the start of the study, the blood sample is taken from the patient. Participants/Inclusion and exclusion criteria: The criteria for Inclusion the study are: known coronary artery disease (based on medical records), history of hospitalization in the CCU, no history of mental illness or lack of use of psychoactive drugs, willingness to participate in the study, Lack of heart failure, Lack of autoimmune diseases, Lack of allergies and immune-related diseases Intervention groups: The sample consisted of 90 participants: , 30 people with coronary artery stenosis receiving routine methods, 30 people with coronary artery stenosis in meditation group,30 people with coronary artery stenosis are in the relaxation group. Main outcome variables: Determination of Serum Levels of IL-10, TGF-β, IL-6, and IFN-γ Cytokines in Patients with Coronary Artery Disease