The aim of our study is to compare the therapeutic effect of pioglitasion and sitagliptin in blood sugar reduction in patients with uncontrolled type 2 diabetes undergoing Metformin treatment ; as a clinical study.According to the including criteria new cases of diabetes with the age of 30-60 years who have the HbA1C between 8-9.5% and BMI between 25 to 35 during the one past year entered our experiment. The predicted volume is 160 patients and are referred to the endocrinology clinic in Vali Asr hospital .The following items were checked in the beginning and at the 3rd month of treatment: HbA1C, TG, Chol, HDL, FBS,Bs 2hpp are analyzed in the laboratory and Blood Pressure, Body Weight will be recorded. . Our patients were randomly divided into two groups{random allocation}. The first group undergoing treatment with Metformin 1 to 2 gr daily and Pioglitasione 15 to 30mg daily, the other group undergoing treatment with Metformin 1 to2 gr daily and sitagliptin 100 to 50mg daily. All the patients were consulted by a nutritionist for the diabetic regimen. Patients were checked monthly to see if the treatment regimen were taken properly and in the case of exclusion criteria in the study will not be.(gastrointestinal and eye and kidney complications).in this study;reduction of HbA1C and FBS and Bs 2hpp as the primary outcome and improvement of lipid profiles and weight loss as a secondary outcome are discussed.