aims: Comparing clarithromycin-based triple therapy Helicobacter pylori eradication with triple therapy containing levofloxacin Inclusion criteria:All patients underwent endoscopy with duodenal ulcer or gastric or duodenal or stomach inflammation and Erosoin Sari hospital clinic professor Gu reported that Helicobacter pylori positive and study are older than 18 years Exit key criteria: During the last two weeks, patients with PPI or H2 RA (histamine 2 receptor antagonist), or within the last 4 weeks have received antibiotics or bismuth; Concomitant use of anticoagulants ;corticosteroids or ketoconazole; Patients with a history of stomach surgery; Patients with peptic ulcer bleeding complication refer and endoscopy used to control bleeding Sample: 120 Intervention and time: Patients with duodenal ulcer or gastric or duodenal or stomach inflammation and erosion after endoscopic diagnosis of Helicobacter pylori positive test randomly placed in two groups A and B ,Patients with duodenal ulcer or gastric or duodenal or stomach inflammation and erosion after endoscopic diagnosis of Helicobacter pylori positive test randomly placed in two groups A and B Patients through random table into randomly receive one of the two regimes. A:pantoprazole 40mg/bd-Amoxicilin1g/-Clarithromycin500/bd B:pantoprazole 40mg/bd-Amoxicilin1g/-levofloxacine500/dailyto 10days