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Study aim: The effect of M1 transcranial direct current stimulation on implicit motor learning in the patients with multiple sclerosis Design: Non-random(Days of the Week (Even and odd)), without placebo . The sample size of this study is 100 individuals: divided into 2 groups of 50 people. Settings and conduct: Neuromuscular Rehabilitation Research Center Semnan University of Medical Sciences. Participants/Inclusion and exclusion criteria: 100 patients with Multiple Sclerosis diagnosis. Inclusion criteria: the age range of 18 to 45 years old; MS patients is detected according to guidelines; have received steady medical and physical therapies since the last 6 months; most are right-handed. Exclusion criteria: Multiple Sclerosis relapses during the last two months; existence severe visual defect on visual examination; existence severe weakness in limbs movement; other neurological and neurological diseases. Intervention groups: Control group: In this group, the brain will receive electrical stimulation for twenty minutes, which will increase in intensity for the first 30 seconds, and then will decrease until the patient feels that there is current and will remain the same until the end of treatment. Intervention group (Brain electrical stimulation): In the intervention group, the active anode electrode is placed on the left side of the brain (C3) and the cathode electrode on the right side of the forearm to stimulate the brain area of the brain. Then an electrical stimulation of 2 mA with a gradual gradient for 20 minutes is applied according to the protocol. Response time is recorded for the task sequences before the intervention, 35 minutes after the intervention and 2 days after the intervention. Main outcome variables: Brain electrical stimulation
IRCTID: IRCT20151228025732N32
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  3. The Effectiveness of Comorbid Transcranial Direct Current Stimulation and Upper Limb Occupational Therapy on Occupational Performance and Fine Motor Movement in People with Multiple Sclerosis: A Randomized Controlled Trial
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