Study aim: Determin the effect of Roy Jelly on quality of life and health status of multiple sclerosis patients Design: The present study is a randomized interventional study will be performed on two groups of 100 patients. Settings and conduct: A study will be conducted on 100 MS patients referring to Hamadan MS Center. In the intervention group, a 500-mg capsule of royal jelly daily is given for one day for 75 days and in a daily control group one placebo for 75 days. Both groups receive the usual treatment according to expert advice. Demographic information will be completed by the researcher at the time the patient enters the department. Quality of life indicators and patient's level of health are completed once before the intervention stage and then 75 days after the intervention using the questionnaire by the researcher. Controls in the control group will not be performed. Participants/Inclusion and exclusion criteria: Inclusion criteria: Age is between 18 and 60 years old, Confirm Diagnosis of MS by the neurologist, Have complete and informed consent to participate in the study Exclusion criteria: Unwillingness to continue participating in the study, Patient death Intervention groups: In the intervention group, a 500-mg capsule of royal jelly daily is given for one day for 75 days and in a daily control group one placebo for 75 days. Both groups receive the usual treatment according to expert advice. Demographic information will be completed by the researcher at the time the patient enters the department. Quality of life indicators and patients' health level are completed once before the intervention stage and then 75 days after the intervention using the questionnaire by the researcher. Main outcome variables: quality of life and health status